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Table of Contents

Ethylene Oxide (EtO or EO) Monitoring Applications
Alarms and Regulatory Compliance
Performance Issues and Third Party Evaluations
Best Practices
Interesting Applications
Hydrogen Peroxide Monitoring Applications
Competitive And Market Issues
Data Logging and Data Acquisition
Calculations and Conversions
Basic Concepts in Measurement Science
Calibration Issues
Risk Management and Keeping It Safe
Gas Concentration Units of Measurement
Demystifying Gas Detection Terminology

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Ethylene Oxide (EtO or EO) Monitoring Applications

A rebuttal to the ChemDAQ vs. Interscan table from ChemDAQ's website

ChemDAQ, a manufacturer of ethylene oxide (EtO) monitoring systems, has posted a pdf of a comparison matrix on its website, pitting their systems against ours. Fair enough. We felt it only proper to reproduce their table, adding a fourth column with our comments. Since the tabular format is not...


Alcohol and Electrochemical Sensors

For any gas to be detectable by an electrochemical sensor, it must first be "electroactive." As defined by the International Union of Pure and Applied Chemistry (IUPAC) Analytical Chemistry Division Commission on Electroanalytical Chemistry, an electroactive substance is... In voltammetry and...


Complying with 40 CFR Part 63 subpart WWWWW--National Emission Standards for Hospital Ethylene Oxide Sterilizers

Background In the continuing regulatory assault on ethylene oxide, more rules now apply. Fortunately, these latest statutes are not at all difficult to comply with. The new rule is called "National Emission Standards for Hospital Ethylene Oxide Sterilizers." It was published on 28 December 2007 as...


EtO Instrumentation Calibration and Surrogate Calibration Techniques

Written in response to a particular inquiry, this article is posted since it is of general interest. Calibration is a very important issue. One of Interscan's competitors recommends calibrating its EtO monitor with CO (Carbon Monoxide). There is nothing wrong with using CO to calibrate an analyzer,...


EtO monitoring systems versus badges

Badges are integrating rather than real-time devices, yielding an accumulated value—often incorrectly interpreted as an "average"—calculated over the time period the badge was active. The advantage of real time monitoring is that it WILL keep track of spikes and excursions, while a...


If an EtO area monitor is installed, are bi-weekly leak tests still required?

The original reference for periodic leak testing comes from 29 CFR 1910.1047 App A, and is entitled "Substance safety data sheet for ethylene oxide (non-mandatory)." Section VII-2-i of the document states: Leak detection. Sterilizer door gaskets, cylinder and vacuum piping, hoses, filters, and...


New requirements for EtO usage

EPA and FIFRA While most matters regarding occupational exposure to toxic compounds—in the United States—fall under the purview of the Occupational Safety & Health Administration (OSHA), in some cases, other federal agencies are also involved. Under the Federal Insecticide, Fungicide,...


Our commentary on OSHA's Small Business Guide for Ethylene Oxide

On 30 April 2009, OSHA released a comprehensive document entitled "Small Business Guide for Ethylene Oxide." This new publication is available as a spiffy pdf (14.2 MB) or as a more browsable web page. The agency considers it to be a "guidance document," in that it is advisory in nature, is...


Predominant EtO Monitoring Methods Used By Hospitals

Gas detection methods have been changing and evolving and awareness has heightened as well, along with the ever changing methods of sterilization. To answer your question regarding what "most" hospitals are using to monitor EtO, a fair response would be narrowed down to either electrochemical...


Why does Interscan offer a 0-50 ppm measuring range for ethylene oxide?

Sometimes, we are asked about the 0-50 ppm measuring range offered on our ethylene oxide (EtO) instruments. After all, a founding principle for direct-reading instruments, used in occupational health work, was that the range should be set up to cover one-tenth to 10 times the TLV-TWA, or as OSHA...


Alarms and Regulatory Compliance

An early study found hydrogen peroxide emissions in sterile processing departments

Hydrogen peroxide (H2O2 or simply "peroxide") has long been the subject of regulatory agency interest. The current allowable 8-hour time weighted average of 1 ppm dates back to 1992, if not earlier. The signs and symptoms of acute exposure to hydrogen peroxide include irritation of the eyes, nose,...


Are there any documents available that provide a frame work or guidance on when a gas detection system should be installed?

It should be noted that long before OSHA, and long before direct-reading instruments were available, people were doing toxic gas detection to protect their employees; combustible gas detection to protect their employees and their facilities; and, of course, they also did this to obtain lower...


Best practices for certain ethylene oxide cylinder operations

This article is based on a request from Frank Denny, Director of the Office of Occupational Safety and Health of the United States Department of Veterans Affairs. During a recent conversation, Mr. Denny had indicated that two of the most frequently asked questions to personnel in his office...


Complying with 40 CFR Part 63 subpart WWWWW--National Emission Standards for Hospital Ethylene Oxide Sterilizers

Background In the continuing regulatory assault on ethylene oxide, more rules now apply. Fortunately, these latest statutes are not at all difficult to comply with. The new rule is called "National Emission Standards for Hospital Ethylene Oxide Sterilizers." It was published on 28 December 2007 as...


Data Logging and Data Acquisition in Gas Detection

Virtually every industrial facility has some kind of gas detection in place: Millions of portable units are in service, and at least a million points of continuous gas detection have been deployed. However, what is being done with all the data? The first and most vital use of this data, of course,...


Hazardous Locations

Background Gas detection instruments must often be used or installed in areas considered to be "hazardous locations." Generically, all sorts of hazards might be recognized in a particular environment, but the term "hazardous locations," as it applies to electrically-operated equipment refers to...


If an EtO area monitor is installed, are bi-weekly leak tests still required?

The original reference for periodic leak testing comes from 29 CFR 1910.1047 App A, and is entitled "Substance safety data sheet for ethylene oxide (non-mandatory)." Section VII-2-i of the document states: Leak detection. Sterilizer door gaskets, cylinder and vacuum piping, hoses, filters, and...


Is it necessary to monitor for hydrogen peroxide in a hospital sterile processing department (SPD) area under "emergency" conditions?

There are two classic aspects of toxic gas detection— a) Monitoring normal employee exposure, to determine if regulatory levels have been exceeded in the long-term b) Monitoring to warn of hazardous levels that might occur in the short term Of course, both of these functions can be...


Is It Necessary To Monitor Ozone Around An Ozone Sterilizer?

With the advent, in 2005, of a practical ozone-based sterilizer by TSO3, Inc. (Model 125L), and its subsequent installation into sterile processing facilities, ChemDAQ added ozone monitoring to its product line. Need we mention that Interscan has offered ozone monitoring instruments for...


Is there a OSHA/DOT or any guideline/regulation that tells me how many ammonia detectors are required in ammonia storage/vaporizer and unloading area?

While guidelines may exist that mandate monitoring of an area for any number of toxic compounds, no official government recommendations are made as to the detailed design of such a monitoring system. In practice, the design of a toxic gas area monitoring system results from a collaboration between...


New requirements for EtO usage

EPA and FIFRA While most matters regarding occupational exposure to toxic compounds—in the United States—fall under the purview of the Occupational Safety & Health Administration (OSHA), in some cases, other federal agencies are also involved. Under the Federal Insecticide, Fungicide,...


Our commentary on OSHA's Small Business Guide for Ethylene Oxide

On 30 April 2009, OSHA released a comprehensive document entitled "Small Business Guide for Ethylene Oxide." This new publication is available as a spiffy pdf (14.2 MB) or as a more browsable web page. The agency considers it to be a "guidance document," in that it is advisory in nature, is...


Using Interscan Analyzers For Method 21 Studies

EPA's Method 21, entitled "Determination Of Volatile Organic Compound Leaks," calls for a portable instrument to be used for this purpose, and details certain specifications and calibration requirements. "Volatile Organic Compounds," better known as VOC's, have been defined by EPA to include in...


Using smart gas detection to comply with GSA's indoor air quality standards

As landlord for the civilian federal government, the Public Buildings Service—a principal division of the General Services Administration (GSA)—owns and leases over 354 million square feet of space in 8,600 buildings in more than 2,200 communities nationwide. For several years, the GSA...


What international codes/standards specify the limiting allowable concentration of flammable, combustible, and toxic gases in indoor and outdoor industrial areas

Most codes and standards—at least regarding allowable concentrations of various substances—are promulgated by domestic jurisdictions, whether at the state/province or national governmental level. However, there are numerous international organizations that publish recommendations on...


Where should I set the alarms on my toxic gas monitoring system?

Note: All exposure limits cited in this article are current as of 31 December 2006 Ultimately, the entire matter of where to set the instantaneous concentration alarm(s) is tied into what is expected by the regulatory agency. In the United States, for most workplace...


Performance Issues and Third Party Evaluations

Pushing The Limits Of Hydrazine Detection At NASA

Ever since Interscan developed a portable hydrazine analyzer for Brooks Air Force Base, way back in the late 1970's, our instruments have been widely deployed in all facets of hypergol (pertaining to fluid propellant) fuel and oxidizer measurements. A new wrinkle was brought in when NASA requested...


Best Practices

Alcohol and Electrochemical Sensors

For any gas to be detectable by an electrochemical sensor, it must first be "electroactive." As defined by the International Union of Pure and Applied Chemistry (IUPAC) Analytical Chemistry Division Commission on Electroanalytical Chemistry, an electroactive substance is... In voltammetry and...


Are there any documents available that provide a frame work or guidance on when a gas detection system should be installed?

It should be noted that long before OSHA, and long before direct-reading instruments were available, people were doing toxic gas detection to protect their employees; combustible gas detection to protect their employees and their facilities; and, of course, they also did this to obtain lower...


Best practices for certain ethylene oxide cylinder operations

This article is based on a request from Frank Denny, Director of the Office of Occupational Safety and Health of the United States Department of Veterans Affairs. During a recent conversation, Mr. Denny had indicated that two of the most frequently asked questions to personnel in his office...


Can a carbon monoxide detector double as a propane gas sniffer?

Thanks for your question. The answer depends on what you mean by "double," and even on how we define "detector." Usually, "detector" means the sensing element within the instrument. But, people sometimes refer to the entire instrument as the detector. Now, if the sensor for carbon monoxide also...


Continuous Monitoring vs. Stream-Switching Monitoring

First, let's define the terms: "Continuous" monitoring means that each sampling point is being monitored all the time, and in most cases, the concentration displayed reflects what is truly happening at the point in real time. There are certain exceptions to this involving instrument techniques...


Detector Tubes And When To Use Them

A detector tube is a graduated glass tube filled with a chemical reagent that will produce a color change, when exposed to the gas in question. It is used with a hand pump that will draw a sample into the tube. The tubes are generally supplied in packages of ten, and are sealed at both ends. In...


EtO monitoring systems versus badges

Badges are integrating rather than real-time devices, yielding an accumulated value—often incorrectly interpreted as an "average"—calculated over the time period the badge was active. The advantage of real time monitoring is that it WILL keep track of spikes and excursions, while a...


Is there a OSHA/DOT or any guideline/regulation that tells me how many ammonia detectors are required in ammonia storage/vaporizer and unloading area?

While guidelines may exist that mandate monitoring of an area for any number of toxic compounds, no official government recommendations are made as to the detailed design of such a monitoring system. In practice, the design of a toxic gas area monitoring system results from a collaboration between...


When I'm buying a toxic gas detection instrument or system, why do I need applications engineering?

Very simply, since no two toxic gas detection applications are the same. We admit that this concept has been obscured under the quite false rubric that "All gas detection is confined entry." Certainly, a goodly percentage of all portable gas detection instruments are designed as if they are...


Where should I set the alarms on my toxic gas monitoring system?

Note: All exposure limits cited in this article are current as of 31 December 2006 Ultimately, the entire matter of where to set the instantaneous concentration alarm(s) is tied into what is expected by the regulatory agency. In the United States, for most workplace...


Interesting Applications

32-point Automation-based CO monitoring system--application details

NOTE: This application was cited in the last section of another Knowledge Base article, and is also referred to here. A large, enclosed, arena-like structure is used for testing heavy construction vehicles. The facility has high ceilings [>50 feet (15.2 m)] to accommodate the large vehicles....


Pushing The Limits Of Hydrazine Detection At NASA

Ever since Interscan developed a portable hydrazine analyzer for Brooks Air Force Base, way back in the late 1970's, our instruments have been widely deployed in all facets of hypergol (pertaining to fluid propellant) fuel and oxidizer measurements. A new wrinkle was brought in when NASA requested...


Using Interscan Analyzers For Method 21 Studies

EPA's Method 21, entitled "Determination Of Volatile Organic Compound Leaks," calls for a portable instrument to be used for this purpose, and details certain specifications and calibration requirements. "Volatile Organic Compounds," better known as VOC's, have been defined by EPA to include in...


Using Interscan analyzers in tainted Chinese drywall inspection and remediation

Following the active hurricane seasons of 2004 and 2005, there was an upsurge in home construction. Demand for drywall exceeded the domestic supply, and a certain amount of drywall was imported from China. In June, 2008, the State of Florida's Department of Health received its first call from a...


Using smart gas detection to comply with GSA's indoor air quality standards

As landlord for the civilian federal government, the Public Buildings Service—a principal division of the General Services Administration (GSA)—owns and leases over 354 million square feet of space in 8,600 buildings in more than 2,200 communities nationwide. For several years, the GSA...


Hydrogen Peroxide Monitoring Applications

An early study found hydrogen peroxide emissions in sterile processing departments

Hydrogen peroxide (H2O2 or simply "peroxide") has long been the subject of regulatory agency interest. The current allowable 8-hour time weighted average of 1 ppm dates back to 1992, if not earlier. The signs and symptoms of acute exposure to hydrogen peroxide include irritation of the eyes, nose,...


Is it necessary to monitor for hydrogen peroxide in a hospital sterile processing department (SPD) area under "emergency" conditions?

There are two classic aspects of toxic gas detection— a) Monitoring normal employee exposure, to determine if regulatory levels have been exceeded in the long-term b) Monitoring to warn of hazardous levels that might occur in the short term Of course, both of these functions can be...


Monitoring hydrogen peroxide in sterile processing departments

For some time, ChemDAQ has been touting its capability of monitoring hydrogen peroxide, in addition to its original EtO product line. As you may be aware, Interscan also offers hydrogen peroxide monitoring instrumentation, and—unlike ChemDAQ—our line includes portable analyzers, as...


Competitive And Market Issues

A rebuttal to the ChemDAQ vs. Interscan table from ChemDAQ's website

ChemDAQ, a manufacturer of ethylene oxide (EtO) monitoring systems, has posted a pdf of a comparison matrix on its website, pitting their systems against ours. Fair enough. We felt it only proper to reproduce their table, adding a fourth column with our comments. Since the tabular format is not...


Can a carbon monoxide detector double as a propane gas sniffer?

Thanks for your question. The answer depends on what you mean by "double," and even on how we define "detector." Usually, "detector" means the sensing element within the instrument. But, people sometimes refer to the entire instrument as the detector. Now, if the sensor for carbon monoxide also...


Continuous Monitoring vs. Stream-Switching Monitoring

First, let's define the terms: "Continuous" monitoring means that each sampling point is being monitored all the time, and in most cases, the concentration displayed reflects what is truly happening at the point in real time. There are certain exceptions to this involving instrument techniques...


Predominant EtO Monitoring Methods Used By Hospitals

Gas detection methods have been changing and evolving and awareness has heightened as well, along with the ever changing methods of sterilization. To answer your question regarding what "most" hospitals are using to monitor EtO, a fair response would be narrowed down to either electrochemical...


What's a Better Methodology for a Toxic Gas Detection System

Definitions A sample draw system uses a pump to draw sample back into the instrument, where it enters the sensor for analysis, and is then exhausted to the atmosphere or vent line. Gas detection instruments with diffusion sensors do not use a pump to pull the sample to the sensor. Instead, they...


When I'm buying a toxic gas detection instrument or system, why do I need applications engineering?

Very simply, since no two toxic gas detection applications are the same. We admit that this concept has been obscured under the quite false rubric that "All gas detection is confined entry." Certainly, a goodly percentage of all portable gas detection instruments are designed as if they are...


Data Logging and Data Acquisition

Data Logging and Data Acquisition in Gas Detection

Virtually every industrial facility has some kind of gas detection in place: Millions of portable units are in service, and at least a million points of continuous gas detection have been deployed. However, what is being done with all the data? The first and most vital use of this data, of course,...


Calculations and Conversions

Correction for Atmospheric Pressure on Gas Detection Instruments

When a gas concentration is measured or reported, we may talk in terms of ppm, but in reality we are measuring the partial pressure of the gas. (Refer to Dalton's Law of Partial Pressures) Thus, any instrument reading is going to be affected by changes in ambient pressure. It is necessary to...


Determining the Dew Point of a Gas Sample

"Dew Point" is defined as the temperature to which a given volume of air must be cooled at constant pressure and constant water vapor content in order for saturation to occur. If the air is cooled further, some of the moisture will condense. The notion of "Saturated Vapor Pressure" can be...


Using Common Sense and Science in Expressing Gas Concentrations

Go directly to conversion calculators Early on, in our first chemistry classes, we learn about solutions, and different ways of expressing their concentrations. Since a solution is any homogeneous mixture of two or more substances, gas mixtures are indeed solutions. In the world of gas detection,...


Basic Concepts in Measurement Science

Accuracy

Definitions"Accuracy" as defined in the ANSI/ISA—51.1—1979 (R1993) standard Process Instrumentation Terminology is:[T]he degree of conformity of an indicated value to a recognized accepted standard value, or ideal value.Two common methods of rating or expressing accuracy are: As a percent of...


Minimum Detectability

"Minimum Detectability" is one of those instrumentation terms that is used frequently, but is seldom defined. Indeed, even though you will encounter this term on many data sheets, its definition does not appear in any of the usual learned references, including Process Instrumentation Terminology,...


Response time, lag time, and when it matters

Interscan provides detailed sensor response data in our Tech Center. Rise time to 90% of final value, rise time to 50% of final value, and fall time to 10% of original value are given for all gases, and specialized sensor types for hydrazine and hydrogen sulfide. It is noted there that the 50%...


Calibration Issues

Calibration Basics

Introduction It is quite unlikely that you will ever use an absolute method for gas detection. Rather, you will employ any one of dozens of "relative" [or "reference," but not necessarily EPA Reference] methods—that is, methods that produce some output that must be calibrated against a known...


Can the detector be calibrated at one concentration to cover the entire range? Since the response is linear, I think the answer is yes. Please confirm. Thanks.

The answer to your question is YES. You are correct in noting that the response of our instruments is linear. More than that, electrochemical voltametric sensors (such as we use) are inherently linear, with no electronic compensation required. However, for optimum accuracy in most applications,...


EtO Instrumentation Calibration and Surrogate Calibration Techniques

Written in response to a particular inquiry, this article is posted since it is of general interest. Calibration is a very important issue. One of Interscan's competitors recommends calibrating its EtO monitor with CO (Carbon Monoxide). There is nothing wrong with using CO to calibrate an analyzer,...


I have seen two numbers relating response of Cl 2 in a ClO 2 detector. One is 3.1 to 1 and the other is 10 to 4, both in favor of ClO 2 . What is the relative response of the Interscan ClO 2 detector and can Cl 2 be used to spot calibrate it?

As you may know, surrogate gas calibration for chlorine dioxide is recommended because it is extremely difficult to generate a stable source of ClO2, especially for practical field use. Indeed, the use of chlorine as a surrogate for chlorine dioxide calibration is one of the very few instances...


In Search of Zero

As discussed in the Calibration Basics Knowledge Base article, Interscan's gas analyzers, and virtually all other direct-reading gas analyzers are not absolute methods. Rather, they employ "relative" [or "reference," but not necessarily EPA Reference] methods. That is, methods that produce some...


Surrogate Calibration

The term "surrogate calibration" refers to a practice in instrument calibration whereby a standard different from the entity to be measured is utilized. For example, thermal flowmeters are based on convective heat transfer effects, and can be calibrated at ambient conditions on a specific gas, and...


What are the calibration techniques available for quantifying a gas? Suggest a few methods for quantifying ammonia in particular.

See our article entitled "Calibration Basics." For ammonia, we would recommend permeation tubes.


Risk Management and Keeping It Safe

Hazardous Locations

Background Gas detection instruments must often be used or installed in areas considered to be "hazardous locations." Generically, all sorts of hazards might be recognized in a particular environment, but the term "hazardous locations," as it applies to electrically-operated equipment refers to...


The Fallacy Of "No Safe Level"

In the wake of the FEMA trailers and the recalled toys from China—to say nothing of the hype surrounding the Consumer Product Safety Improvement Act of 2008 (CPSIA)—you may have heard some pundit say that "There is no safe level of (fill in the name of your favorite toxic substance)."...


Understanding Danger

The dictionary defines "danger" as "the state of being exposed to harm : liability to injury, pain, or loss." Typically, gas detection is deployed in areas that contain potential danger. This danger may result from some sort of upset condition, as in a leak—representing an immediate toxic or...


Gas Concentration Units of Measurement

More on Expressing Gas Concentrations

This is a follow-up to our earlier article on Using Common Sense and Science in Expressing Gas Concentrations, inspired by a real-life adventure of one of our sales engineers. As our hero was slogging through some e-mail inquiries, he came upon two units of measurement he had not seen...


Using Common Sense and Science in Expressing Gas Concentrations

Go directly to conversion calculators Early on, in our first chemistry classes, we learn about solutions, and different ways of expressing their concentrations. Since a solution is any homogeneous mixture of two or more substances, gas mixtures are indeed solutions. In the world of gas detection,...


When is a part-per-billion (ppb) NOT a part-per-billion (ppb)?

As if it weren't bad enough that clueless environmental authorities try to impose their ignorance on the field by using so-called "metric" units of gas concentration, another trap may be lurking for you. Everyone around the world agrees that a part-per-million (ppm) equals 10-6. Unfortunately,...


Demystifying Gas Detection Terminology

Accuracy

Definitions"Accuracy" as defined in the ANSI/ISA—51.1—1979 (R1993) standard Process Instrumentation Terminology is:[T]he degree of conformity of an indicated value to a recognized accepted standard value, or ideal value.Two common methods of rating or expressing accuracy are: As a percent of...


Is there a diference between gas detector and gas monitor? If so what is the difference? How do we know that a piece of equipment is a monitor and not a detector?

In many cases, the terms "gas detector" and "gas monitor" are used interchangeably, and this can lead to confusion. When the word "detector" is mentioned in the context of a detector tube, it is clear that we are referring to short term or even one-shot grab sample measurements. Moreover, when...


Minimum Detectability

"Minimum Detectability" is one of those instrumentation terms that is used frequently, but is seldom defined. Indeed, even though you will encounter this term on many data sheets, its definition does not appear in any of the usual learned references, including Process Instrumentation Terminology,...


Response time, lag time, and when it matters

Interscan provides detailed sensor response data in our Tech Center. Rise time to 90% of final value, rise time to 50% of final value, and fall time to 10% of original value are given for all gases, and specialized sensor types for hydrazine and hydrogen sulfide. It is noted there that the 50%...


When is a part-per-billion (ppb) NOT a part-per-billion (ppb)?

As if it weren't bad enough that clueless environmental authorities try to impose their ignorance on the field by using so-called "metric" units of gas concentration, another trap may be lurking for you. Everyone around the world agrees that a part-per-million (ppm) equals 10-6. Unfortunately,...